Marin Plus Liver Health Supplement Logo

Armor for the dog's liver

Why a liver health supplement?

The liver participates in many activities within the body. It helps the digestion of food through production of bile and helps change digested foods into substances used by the body for energy and growth. The liver stores vitamins and minerals and works with sugars (carbohydrates, glucose), fats, and proteins. The liver also helps to filter the blood.

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When liver function is compromised, the exact reason can often be difficult to determine. Supporting the liver, regardless of the reason, is essential to help keep it working properly.


Why a liver health supplement?

Marin Plus helps provide support for the liver with silybin (from the milk thistle plant), vitamin E, zinc, medium chain triglyceride (MCT) oil, and curcumin (the active ingredient in turmeric).

Marin Plus Shield
  • Liver-protective
  • Helps support healthy inflammatory response
  • Helps support oxidative balance
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  • Energy source for metabolic reactions in the liver
  • Helps reduce fat deposition in the liver
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  • Antioxidant effects: Enhances glutathione levels
  • Shown in cell culture to inhibit inflammatory mediators
  • Increases bile flow
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  • Antioxidant effects
  • Essential nutrient
  • Levels are often low in dogs with compormised liver function
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  • Antioxidant effects
  • Anti-fibrotic
  • Essential cofactor in a number of biological reactions

The chart below illustrates that the Silybin in Marin Plus (which is in a phosphatidylcholine complex) has increased absorption in dogs, reaching levels up to 4 times more than that seen with 80% standardized milk thistle extracts (silymarin).

Plasma levels of silybin in dogs after oral administration of SPC* versus oral administration of silymarin Marin Plus Bioavailability Chart
Each is given as one oral dose equivalent to 16 mg/kg body weight of silybin.

Filburn CR, Kettenacker R, Griffin D. Safety and bioavailability in beagles of zinc and vitamin E combined with silybin and phosphatidylcholine. Inten J Appl Res Med 2006;4(4):326-334.

*Silybin-phosphatidylcholine complex

The NMXCC95 curcumin extract in Marin Plus also has enhanced absorption. As seen in the chart below, NMXCC95 extract was shown to have 7x higher overall absorption and 3x higher maximal levels in the bloodstream than standard curcumin extract.

Marin Plus Curcumin Chart

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Marin Plus Liver Health Supplement
  • Helps support the dog's liver with five key ingredients:
    • Silybin A & B (from milk thistle)
    • Vitamin E
    • Zinc
    • Medium Chain Triglyceride (MCT) Oil
    • Curcumin Extract
  • Convenient administration in a tasty soft chew
  • Can be used in conjunction with Denosyl® or Denamarin® when enhanced liver support is needed
Medium Dogs

Directions for Use:

Marin® Plus must be given with food. A convenient way is to crumble it on your dog’s food.
Dog's Weight (lbs) Number of Soft Chews Per Day
10 - 14 1 Every Other Day
15 - 29 1
30 - 59 2
60 - 89 3

For dogs over 90 lbs, administer an additional soft chew for every 30 lbs. Store in a cool, dry area out of direct sunlight. Reseal closure securely after opening to ensure freshness. Keep out of the reach of children.

What is Marin® Plus?

Marin Plus is a combination of ingredients providing a comprehensive approach to liver support. The active ingredients in Marin Plus are silybin, vitamin E, zinc, medium chain triglyceride (MCT) oil, and curcumin extract.

How can Marin Plus help my pet's liver?

Silybin is an active part of an extract from the milk thistle known as silymarin. Silybin/silymarin has been shown to support liver function by acting as an antioxidant. This means that it helps to counteract or protect against the harmful effects on the liver of “reactive” oxygen compounds. Silybin helps the flow of bile through the liver. Bile contains digestive enzymes along with other substances and aids in digestion and absorption of nutrients from your pet’s diet. Additionally, silybin may support levels of a substance called glutathione, which is the liver’s major “detoxifying” agent. Vitamin E is an antioxidant that has also been shown to help protect liver function. Zinc supplementation may be beneficial in dogs with long-term decreased liver function as these dogs often have low liver zinc levels. Zinc also has antioxidant effects. Zinc participates in many enzymatic reactions within the body, and any deficiency may have harmful effects. MCT oil acts as an easily absorbed energy source for the liver. Curcumin extract inhibits the inflammatory pathway and supports oxidative balance.

How will I know if Marin Plus is helping my pet?

Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Marin Plus and how it is helping your dog’s liver function. At home, watch for a response in attitude, appetite, and activity level.

How do I give Marin Plus to my pet and how much should I give?

Marin Plus is formulated in a tasty soft chew that should be given with food. Please see Directions for Use above or on pouch.

How long should I continue to give Marin Plus?

Marin Plus is often given for an extended time to continue the benefits to your pet’s health. Based on your pet’s response, your veterinarian will provide you with specific advice on how long your pet should take Marin Plus.

Are there any interactions between the ingredients in Marin Plus and other products?

There are no known interactions between the ingredients in Marin Plus and any drug or other supplement. In some cases your veterinarian may recommend giving Marin Plus with a product known as Denosyl® or Denamarin®.

Do the ingredients in Marin Plus cause any side effects?

There are no known side effects with silybin/silymarin in dogs or cats. Vitamin E is also well-tolerated in recommended amounts. Zinc is usually well-tolerated when given in recommended amounts, though occasionally gastrointestinal upset may be seen. To minimize the possibility of any zinc sensitivity in some dogs, it is recommended that Marin Plus be given with food. MCT oil and curcumin extract are also well tolerated. There are no known contraindications to the use of the ingredients in Marin Plus.

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Marin Plus Liver Health Supplement from Nutramax Laboratories Veterinary Sciences, Inc.