The chart below illustrates that the Silybin in Marin Plus (which is in a phosphatidylcholine complex) has increased absorption in dogs, reaching levels up to 4 times more than that seen with 80% standardized milk thistle extracts (silymarin).
Filburn CR, Kettenacker R, Griffin D. Safety and bioavailability in beagles of zinc and vitamin E combined with silybin and phosphatidylcholine. Inten J Appl Res Med 2006;4(4):326-334.
*Silybin-phosphatidylcholine complex
The NMXCC95™ curcumin extract in Marin Plus also has enhanced absorption. As seen in the chart below, NMXCC95™ extract was shown to have 7x higher overall absorption and 3x higher maximal levels in the bloodstream than standard curcumin extract.
| Dog's Weight (lbs) | Number of Soft Chews Per Day |
|---|---|
| 10 - 14 | 1 Every Other Day |
| 15 - 29 | 1 |
| 30 - 59 | 2 |
| 60 - 89 | 3 |
For dogs over 90 lbs, administer an additional soft chew for every 30 lbs. Store in a cool, dry area out of direct sunlight. Reseal closure securely after opening to ensure freshness. Keep out of the reach of children.
Marin Plus is a combination of ingredients providing a comprehensive approach to liver support. The active ingredients in Marin Plus are silybin, vitamin E, zinc, medium chain triglyceride (MCT) oil, and curcumin extract.
Silybin is an active part of an extract from the milk thistle known as silymarin. Silybin/silymarin has been shown to support liver function by acting as an antioxidant. This means that it helps to counteract or protect against the harmful effects on the liver of “reactive” oxygen compounds. Silybin helps the flow of bile through the liver. Bile contains digestive enzymes along with other substances and aids in digestion and absorption of nutrients from your pet’s diet. Additionally, silybin may support levels of a substance called glutathione, which is the liver’s major “detoxifying” agent. Vitamin E is an antioxidant that has also been shown to help protect liver function. Zinc supplementation may be beneficial in dogs with long-term decreased liver function as these dogs often have low liver zinc levels. Zinc also has antioxidant effects. Zinc participates in many enzymatic reactions within the body, and any deficiency may have harmful effects. MCT oil acts as an easily absorbed energy source for the liver. Curcumin extract inhibits the inflammatory pathway and supports oxidative balance.
Your veterinarian will likely recommend follow-up examinations, blood work, and/or other laboratory work to check on how well your pet is doing with Marin Plus and how it is helping your dog’s liver function. At home, watch for a response in attitude, appetite, and activity level.
Marin Plus is formulated in a tasty soft chew that should be given with food. Please see Directions for Use above or on pouch.
Marin Plus is often given for an extended time to continue the benefits to your pet’s health. Based on your pet’s response, your veterinarian will provide you with specific advice on how long your pet should take Marin Plus.
There are no known interactions between the ingredients in Marin Plus and any drug or other supplement. In some cases your veterinarian may recommend giving Marin Plus with a product known as Denosyl® or Denamarin®.
There are no known side effects with silybin/silymarin in dogs or cats. Vitamin E is also well-tolerated in recommended amounts. Zinc is usually well-tolerated when given in recommended amounts, though occasionally gastrointestinal upset may be seen. To minimize the possibility of any zinc sensitivity in some dogs, it is recommended that Marin Plus be given with food. MCT oil and curcumin extract are also well tolerated. There are no known contraindications to the use of the ingredients in Marin Plus.
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